Protein Details: Potassium voltage-gated channel subfamily H member 6

Protein ID

ICDB_Pro_1506

Protein Name

Potassium voltage-gated channel subfamily H member 6

Gene Name

KCNH6; ERG2

Organism

Homo sapiens (Human)

Length

994 amino acids

AlphaFoldDB

AF-Q9H252-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating;rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly

Sequence

MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHPDAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

594..711

Disease

Primary Amebic Meningoencephalitis and Mediastinum Leiomyoma

Location

Expressed in prolactin-secreting adenomas.

DOI ID

10.1038/ng1285; 10.1101/gr.2596504; 10.1007/s00424-002-0980-0; 10.1074/mcp.m800504-mcp200

RefSeq

NP_001265848.1; NP_001265849.1; NP_110406.1 [Q9H252-1]; NP_775115.1 [Q9H252-2]; XP_011523612.1 [Q9H252-2]; XP_016880664.1 [Q9H252-1]